ea0021p326 | Reproduction | SFEBES2009
Peltoketo Hellevi
, Strauss Leena
, Karjalainen Riikka
, Zhang Meilin
, Stamp Gordon
, Segaloff Deborah
, Poutanen Matti
, Huhtaniemi Ilpo
Strong gain-of-function mutations have not been identified in humans in the FSH receptor (FSHR), while such mutations are common among many other G-protein-coupled receptors. In order to predict consequences of such mutations on humans, D580 (D6.44) mutant forms of mouse (m) FSHR were expressed under the human anti-Müllerian hormone promoter in transgenic mice. Transgenic expression of mFshrD580H in granulosa cells led to abnormal ovarian structur...